Case Study
From phase III trial analysis to 10 year evaluation of outcomes and cost: assessing transplantation risk and benefits
Objectives: To translate short-term phase III trial results into robust long-term health economic analyses
Research
- A systematic literature review was conducted to provide inputs for an economic model with a focus on:
- Quality of life
- Health utilities
- Cost of illness (direct costs)
- Health economic analyses
- Adverse events
- Resource utilization (including hospitalizations)
- Data for the following key model parameters were evaluated and extracted:
- Transition probabilities
- Utilities
- Cost data
Analyze
- A descriptive analysis of a phase III trial data was performed with respect to hospitalization rates, length of stay, and causes
- A Markov cost-utility model framework was developed with short-term data inputs from a clinical trial and long-term data inputs from literature
- Analyses for the US healthcare setting (including sensitivity analyses) were performed over a 10 year time horizon
Communicate
- Provided model with comprehensive documentation for global internal dissemination
- Offered support for country specific model adaptations and analyses
- Prepared abstracts, conference presentations, and manuscripts
- Presentations accepted at two major transplantation congresses
- Publication in leading clinical journal
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